Attenuation of Diastolic Heart Failure and Life-Threatening Ventricular Tachyarrhythmia After Peripheral Blood Stem Cell Transplantation Combined With Cardioverter-Defibrillator Implantation in Myeloma-Associated Cardiac Amyloidosis

Hiroyuki Yaoita; Masumi Iwai-Takano; Kazuei Ogawa; Hitoshi Suzuki; Kazuko Akutsu; Hideyoshi Noji; Yoshiyuki Kamiyama; Satoshi Kimura; Hideki Ohtake; Toshiyuki Ishibashi; Yukio Maruyama

doi:10.1253/circj.72.331

Case Report

Attenuation of Diastolic Heart Failure and Life-Threatening Ventricular Tachyarrhythmia After Peripheral Blood Stem Cell Transplantation Combined With Cardioverter-Defibrillator Implantation in Myeloma-Associated Cardiac Amyloidosis

Hiroyuki Yaoita, Masumi Iwai-Takano, Kazuei Ogawa, Hitoshi Suzuki, Kazuko Akutsu, Hideyoshi Noji, Yoshiyuki Kamiyama, Satoshi Kimura, Hideki Ohtake, Toshiyuki Ishibashi, Yukio Maruyama

Author information

Hiroyuki Yaoita
First Department of Internal Medicine, Fukushima Medical University
Masumi Iwai-Takano
First Department of Internal Medicine, Fukushima Medical University
Kazuei Ogawa
First Department of Internal Medicine, Fukushima Medical University
Hitoshi Suzuki
First Department of Internal Medicine, Fukushima Medical University
Kazuko Akutsu
First Department of Internal Medicine, Fukushima Medical University
Hideyoshi Noji
First Department of Internal Medicine, Fukushima Medical University
Yoshiyuki Kamiyama
First Department of Internal Medicine, Fukushima Medical University
Satoshi Kimura
First Department of Internal Medicine, Fukushima Medical University
Hideki Ohtake
First Department of Internal Medicine, Fukushima Medical University
Toshiyuki Ishibashi
First Department of Internal Medicine, Fukushima Medical University
Yukio Maruyama
First Department of Internal Medicine, Fukushima Medical University

Keywords: Amyloid, Arrhythmia, Cardiomyopathy, Heart failure, Transplantation

JOURNAL FREE ACCESS

2008 Volume 72 Issue 2 Pages 331-334

DOI https://doi.org/10.1253/circj.72.331

Details

Abstract

A patient had multiple myeloma and associated cardiac amyloidosis, which caused diastolic dysfunction and recurrent ventricular fibrillation. After implantation of a cardioverter-defibrillator (ICD), the patient underwent autologous peripheral blood stem cell transplantation (PBSCT). The life-threatening arrhythmias, such as ventricular fibrillation, disappeared, and diastolic dysfunction assessed by quantitative gated single photon emission computed tomography and Doppler echocardiography improved 7 months later. This may be the first report to document improvement of both a lethal rhythm disorder and diastolic dysfunction by PBSCT following ICD implantation in a case of cardiac amyloidosis associated with multiple myeloma. (Circ J 2008; 72: 331 - 334)

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