Effects of Metabolic Risk Factors on Production of Plasminogen Activator Inhibitor-1 and Adiponectin by Adipocytes

Abstract

Background Type 1 plasminogen activator inhibitor (PAI-1) and adiponectin are produced by adipocytes and are important in the progression of coronary artery disease (CAD). Methods and Results Different concentrations of glucose, insulin and 1% triglycerides were used to assay PAI-1 and adiponectin production from cultured adipocytes. Triglycerides induced the highest PAI-1 production with 16.5 mmol/L glucose and 50 nmol/L insulin. In contrast, glucose and insulin decreased adiponectin production in a dose-dependent manner irrespective of triglycerides. Conclusion The metabolic syndrome risk factors alter PAI-1 and adiponectin production by adipocytes, in the presence or absence of triglycerides, which might play a role in the development of CAD. (Circ J 2008; 72: 844 - 846)