Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Clinical Investigation
Clinical Outcomes and Therapeutic Strategy in Patients With Acute Myocardial Infarction According to Renal Function
Data From the Korean Acute Myocardial Infarction Registry
Sang-Hee LeeYoung-Jo KimWoong KimJong-Seon ParkDong-Gu ShinSeung-Ho HurChong-Jin KimMyeong-Chan ChoShung-Chull ChaeMyung-Ho JeongTaek-Jong HongDoo-Il KimKee-Sik KimKorean Acute Myocardial Infarction Registry Investigators
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2008 Volume 72 Issue 9 Pages 1410-1418


Background The aim of the present study was to evaluate the relationship between clinical outcomes after acute myocardial infarction (MI) and renal function by glomerular filtration rate (GFR) in patients with normal or mildly elevated serum creatinine concentrations. Methods and Results As part of the Korean Acute Myocardial Infarction Registry (KAMIR), 6,834 acute MI patients with a serum creatinine concentration of ≤2.0 mg/dl were enrolled from November 2005 to December 2006. The renal function was stratified arbitrary to 5 groups: (1) normal function, >90.0; (2) preserved function, 75.0-89.9; (3) mild dysfunction, 60.0-74.9; (4) moderate dysfunction, 45.0-59.9; (5) severe dysfunction, <45 ml · min-1 · 1.73 m-2. Clinical characteristics, mortality and adverse events were analyzed among each group. Although reperfusion and medical therapies were underused, the rates of mortality and adverse events were increased with declining renal function. After adjustment with confounders, severe and moderate renal dysfunctions were important risk predictors of in-hospital mortality, long-term mortality and adverse events. Conclusion The spectrum of renal function, when it was presented by GFR, is broad and is an important risk predictor for adverse outcomes after acute MI, even in patients with normal or mildly elevated serum creatinine concentrations. Furthermore, standard treatments were underused in any degree of renal dysfunction. (Circ J 2008; 72: 1410 - 1418)

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