Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Arrhythmia/Electrophysiology
Ambulatory ECG-Based T-Wave Alternans and Heart Rate Turbulence Predict High Risk of Arrhythmic Events in Patients With Old Myocardial Infarction
Shingo MaedaMitsuhiro NishizakiNoriyoshi YamawakeTakashi AshikagaHiroshi ShimadaMitsutoshi AsanoKensuke IharaTadashi MuraiHidetoshi SuzukiHiroyuki FujiiHarumizu SakuradaMasayasu HiraokaMitsuaki Isobe
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2009 Volume 73 Issue 12 Pages 2223-2228

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Abstract

Background: Few studies have explored risk stratification of arrhythmic events in patients with ischemic heart diseases according to T-wave alternans (TWA) using modified moving average (MMA) method and heart rate turbulence (HRT). Methods and Results: A retrospective analysis of 63 patients who underwent MMA-based TWA and HRT divided the patients into 3 groups: group-C of 21 controls, group-O of 21 patients with old myocardial infarction (OMI) showing no episodes of sustained ventricular tachyarrhythmia (SVT), and group-V of 21 OMI patients with episodes of SVT who received an implantable cardioverter-defibrillator. Among the 3 groups, positive TWA (≥65 μV) and impaired HRT were observed most frequently in group-V (P<0.05). Using a logistic regression model, TWA yielded an odds ratio of 4.9 (95% confidence interval: 1.2-19.6, P<0.05), which was the only significant covariate for the incidence of life-threatening ventricular arrhythmias during a mean follow-up of 72 months. Conclusions: Patients with OMI showing episodes of SVT have a high risk for cardiac death because of abnormal repolarization and autonomic regulation. The analysis of MMA-based TWA and HRT can be a useful tool for predicting OMI patients at high risk of arrhythmic events. (Circ J 2009; 73: 2223-2228)

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© 2009 THE JAPANESE CIRCULATION SOCIETY
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