Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
Arrhythmia/Electrophysiology
Metabolic Syndrome and Risk of Recurrence of Atrial Fibrillation After Catheter Ablation
Ri-Bo TangJian-Zeng DongXing-Peng LiuDe-Yong LongRong-Hui YuJérôme KalifaChang-Sheng Ma
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2009 Volume 73 Issue 3 Pages 438-443

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Abstract

Background: Metabolic syndrome (MetS), as well as several risk factors of cardiovascular diseases, is known to be associated with atrial fibrillation (AF), but its impact on the recurrence of AF after catheter ablation has not been explored. Methods and Results: The data for 654 consecutive AF patients who underwent an index circumferential pulmonary vein ablation were retrospectively analyzed. Of them, 323 (49.4%) had MetS according to the modified National Cholesterol Education Program-Adult Treatment Panel III criteria and Chinese ethnic criteria. After a mean follow-up of 470±323 (91-1,245) days, patients with MetS had a significantly higher incidence of AF recurrence (43.7%) compared with non-MetS patients (30.5%, P<0.001). Univariate analysis revealed that nonparoxysmal AF, left atrial size, MetS and body mass index were predictors of AF recurrence. Multivariate analysis revealed that MetS (hazard ratio =1.64, 95% confidence interval (CI) 1.07-2.49, P=0.022) and nonparoxysmal AF (hazard ratio =1.57, 95% CI 1.15-2.14, P=0.004) were independent predictors of AF recurrence. The major complications rate did not differ between the MetS and the non-MetS groups (1.86% vs 2.42%, P=0.621). Conclusions: MetS diagnosed prior to AF ablation is an independent predictor of AF recurrence. (Circ J 2009; 73: 438 - 443)

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© 2009 THE JAPANESE CIRCULATION SOCIETY
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