Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
Regenerative Medicine
Improvement of Cardiac Function by Intracoronary Freshly Isolated Bone Marrow Cells Transplantation in Patients With Acute Myocardial Infarction
Ramazan Gökmen TuranIlkay Bozdag-TuranJasmin OrtakIbrahim AkinStephan KischeHenrik SchneiderTim Christopher RehdersCem Hakan TuranMathias RauchhausTilo KleinfeldtTuschar ChatterjeeKurtulus SahinChristoph A. NienaberHüseyin Ince
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2011 Volume 75 Issue 3 Pages 683-691

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Abstract

Background: We analyzed in the present study the influence of intracoronary autologous freshly isolated bone marrow cells transplantation (BMCs-Tx) on cardiac function in patients with acute myocardial infarction (AMI). Methods and Results: The 32 patients with AMI were enrolled in this prospective nonrandomized study to either freshly isolated BMC-Tx or to a control group without cell therapy. Global left ventricular ejection fraction (LVEF) and the size of infarct area were determined by left ventriculography. We observed in patients with autologous freshly isolated BMCs-Tx at 6 months follow up a significant reduction of infarct size as compared to control group. Moreover, we found a significant increase of LVEF as well as infarct wall movement velocity at 6 months follow up in cell therapy group as compared to control group. In the control group there was no significant difference of LVEF, infarct size and infarct wall movement velocity between baseline and 6 months after AMI. Conclusions: These results demonstrate for the first time that intracoronary transplantation of autologous freshly isolated BMCs by use of a point of care system is safe, and may lead to improvement of cardiac function in patients with AMI. (Circ J 2011; 75: 683-691)

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© 2011 THE JAPANESE CIRCULATION SOCIETY
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