Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Imaging
Transmural Perfusion Gradient in Adenosine Triphosphate Stress Myocardial Perfusion Computed Tomography
Kohei HosokawaAkira KurataTeruhito KidoFumiaki ShikataHiroshi ImagawaKanji KawachiAkiyoshi OgimotoJitsuo HigakiTomoyuki KidoHiroshi HigashinoTeruhito Mochizuki
Author information
JOURNALS FREE ACCESS

2011 Volume 75 Issue 8 Pages 1905-1912

Details
Abstract

Background: The aim of the present study was to assess semi-quantification of myocardial perfusion using adenosine triphosphate (ATP)-stress myocardial perfusion computed tomography (MPCT) in patients with coronary artery disease (CAD).Methods and Results: Seventeen patients with CAD underwent ATP-stress MPCT, stress myocardial perfusion scintigraphy (MPS) and coronary angiography (CAG). With ATP loading (0.16mg·kg-1·min-1, 5min) and slow infusion of contrast medium (2ml/s, 100ml), stress images were acquired using prospective electrocardiogram-gated 64-slice CT. Stress MPCT images were analyzed according to the transmural perfusion gradient (TMPG; difference between subendocardial and epicardial attenuation, divided by wall thickness; Hounsfield units [HU]/mm) per segment, and summed TMPG was compared with those of stress MPS and CAG per territory and patient, respectively. There were 36 CAG-proved stenotic vessels in 51 (17×3) territories. There were significant correlations between TMPG and MPS stress score per segment, per territory and per patient, respectively (P<0.05). Summed TMPG in territories with and without >70% coronary stenosis was 32.3HU/mm (-1.9~90.9) and 14.5HU/mm (-5.6~38.4; P<0.05). For detecting coronary artery stenosis, sensitivity, specificity, positive and negative predictive values using the summed TMPG were 72%, 87%, 93% and 57%, in comparison with summed MPS (64%, 73%, 85%, and 46%).Conclusions: Semi-quantification of myocardial perfusion using TMPG has great potential to evaluate the severity of myocardial ischemia, similarly to MPS score. (Circ J 2011; 75: 1905-1912)

Information related to the author
© 2011 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
feedback
Top