Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Ischemic Heart Disease
High-Density Lipoprotein Cholesterol Level Is Associated With Fibrous Cap Thickness in Acute Coronary Syndrome
Yuichi OzakiAtsushi TanakaKenichi KomukaiKohei IshibashiTakashi TanimotoHironori KitabataYasushi InoTakashi KuboToshio ImanishiTakashi Akasaka
Author information
JOURNALS FREE ACCESS

2013 Volume 77 Issue 12 Pages 2982-2989

Details
Abstract

Background: Although low high-density lipoprotein cholesterol (HDL-C) level has been reported as an independent risk factor for coronary artery disease, few studies addressed the direct relationship between the presence of thin-cap fibroatheroma (TCFA) that is considered as vulnerable plaque in pathology and HDL-C level. The aim of this study was to investigate whether lesion vulnerability is related to HDL-C level in patients with acute coronary syndrome (ACS). Methods and Results: A total of 261 patients with ACS who underwent optical coherence tomography prior to percutaneous coronary intervention, were enrolled. Patients were divided into a TCFA group (n=124) and a non-TCFA group (n=137). TCFA was defined as a lipid plaque (lipid content in ≥1 quadrant) covered with <70m-thickness fibrous caps. There were no differences in patient characteristics and clinical results between the 2 groups except for HDL-C level, low-density lipoprotein cholesterol (LDL-C) level, and high-sensitive C-reactive protein (hs-CRP) level. On multivariate regression analysis, low HDL-C level (β coefficient: 0.302, P<0.001), high LDL-C level (β coefficient: −0.172, P=0.008), hs-CRP level (β coefficient: −0.145, P=0.017), and current smoking (β coefficient: −0.124, P=0.028) were identified as independent contributors to fibrous cap thickness. Conclusions: HDL-C is correlated with fibrous cap thickness of the culprit lesion in patients with ACS. HDL-C may be considered as a therapeutic target for plaque stabilization.  (Circ J 2013; 77: 2982–2989)

Information related to the author
© 2013 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
feedback
Top