Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Reviews
Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore
John W. ElrodJeffery D. Molkentin
Author information
JOURNALS FREE ACCESS

2013 Volume 77 Issue 5 Pages 1111-1122

Details
Abstract

This review focuses on the role of cyclophilin D (CypD) as a prominent mediator of the mitochondrial permeability transition pore (MPTP) and subsequent effects on cardiovascular physiology and pathology. Although a great number of reviews have been written on the MPTP and its effects on cell death, we focus on the biology surrounding CypD itself and the non-cell death physiologic functions of the MPTP. A greater understanding of the physiologic functions of the MPTP and its regulation by CypD will likely suggest novel therapeutic approaches for cardiovascular disease, both dependent and independent of programmed necrotic cell death mechanisms.  (Circ J 2013; 77: 1111–1122)

Information related to the author
© 2013 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
feedback
Top