Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
Cardiac Rehabilitation
Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein
Akira TakashimaTakayuki IseShusuke YagiTakashi IwaseSahika KimuraYuka UedaKoji NishikawaAyumi IshiiToshiyuki NikiKoji YamaguchiYoshio TaketaniHirotsugu YamadaTakeshi SoekiTetsuzo WakatsukiShinsuke KatohMasashi AkaikeMasataka Sata
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2014 Volume 78 Issue 11 Pages 2682-2687

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Abstract

Background:Oxidized low-density lipoprotein (oxLDL) levels have been found to play an important role in the progression of atherosclerosis. However, methods for effectively reducing oxLDL levels have not been established. Comprehensive cardiac rehabilitation (CR) with exercise training prevents the progression of atherosclerosis, and might reduce oxLDL levels.Methods and Results:We measured the serum levels of malondialdehyde-modified LDL (MDA-LDL), a marker of oxLDL, in 136 patients who were enrolled in a 6-month CR program. Peak oxygen consumption (V̇O2) and MDA-LDL levels were analyzed, before and 6 months after enrolment. In total, 67 patients completed the CR program (CR group) and 69 patients failed to complete the program (non-CR group). Peak V̇O2increased significantly in the CR group (P<0.01). The levels of MDA-LDL decreased significantly in the CR group (P<0.01) but not in the non-CR group. ∆V̇O2(peak V̇O2after CR–peak V̇O2before CR) was negatively associated with ∆MDA-LDL (MDA-LDL after CR–MDA-LDL before CR) (R2=0.11, P=0.01). Multiple regression analysis showed that continuing CR was an independent determining factor for lowering MDA-LDL levels.Conclusions:CR decreases oxLDL levels in patients with cardiovascular diseases. Moreover, CR may prevent cardiovascular events through an antioxidative effect. (Circ J 2014; 78: 2682–2687)

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© 2014 THE JAPANESE CIRCULATION SOCIETY
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