Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Cardiovascular Intervention
Favorable Vessel Healing After Nobori Biolimus A9-Eluting Stent Implantation
– 6- and 12-Month Follow-up by Optical Coherence Tomography –
Akihide KonishiToshiro ShinkeHiromasa OtakeTomofumi TakayaMasayuki NakagawaTakumi InoueHirotoshi HarikiTsuyoshi OsueYu TaniguchiMasamichi IwasakiRyo NishioNoritoshi HiranumaHiroto KinutaniMasaru KurodaHachidai TakahashiDaisuke TerashitaJunya ShiteKen-ichi Hirata
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2014 Volume 78 Issue 8 Pages 1882-1890

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Abstract

Background:Nobori is a novel biolimus A9-eluting stent (BES) coated with a biodegradable polymer only on the abluminal side, which degrades over 6–9 months post-stent deployment. The course of vessel reaction after deployment at these time points remains unclear.Methods and Results:We serially evaluated 28 BES implanted in de novo coronary lesions of 23 patients using optical coherence tomography (OCT) at 6 and 12 months post-stenting. Standard OCT variables, the percentage of stent with peri-strut low-intensity area (PLIA, a region around stent struts homogenously showing lesser intensity than the surrounding tissue, suggesting fibrin deposition or impaired neointima maturation) and that with in-stent thrombi were evaluated. There was a significant, but small increase in neointimal thickness (72±23 to 82±25 µm, P=0.006) from the 6- to the 12-month follow-up, without a significant decrease in minimum lumen area (P=0.30). The incidences of uncovered and malapposed struts were low at 6 months and reduced further at 12 months (3.96±3.97% to 1.51±1.63%, P=0.001, and 0.50±1.84% to 0.06±0.24%, P=0.20, respectively). The frequency of stent with PLIA decreased during the follow-up (57% to 32%, P=0.05) and that with in-stent thrombi also numerically decreased (7% to 0%, P=0.24).Conclusions:Neointimal hyperplasia was persistently suppressed following BES implantation up to 12 months. Simultaneously, favorable vessel healing was achieved at 6 months without a delaying adverse reaction for up to 12 months. (Circ J 2014; 78: 1882–1890)

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© 2014 2013 THE JAPANESE CIRCULATION SOCIETY
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