Increased Coronary Perivascular Adipose Tissue Volume in Patients With Vasospastic Angina

Kazuma Ohyama; Yasuharu Matsumoto; Kensuke Nishimiya; Kiyotaka Hao; Ryuji Tsuburaya; Hideki Ota; Hirokazu Amamizu; Hironori Uzuka; Jun Takahashi; Kenta Ito; Hiroaki Shimokawa

doi:10.1253/circj.CJ-16-0213

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Increased Coronary Perivascular Adipose Tissue Volume in Patients With Vasospastic Angina

Kazuma Ohyama, Yasuharu Matsumoto, Kensuke Nishimiya, Kiyotaka Hao, Ryuji Tsuburaya, Hideki Ota, Hirokazu Amamizu, Hironori Uzuka, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

Author information

Kazuma Ohyama
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Yasuharu Matsumoto
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Kensuke Nishimiya
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Kiyotaka Hao
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Ryuji Tsuburaya
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Hideki Ota
Department of Diagnostic Radiology, Tohoku University Hospital
Hirokazu Amamizu
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Hironori Uzuka
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Jun Takahashi
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Kenta Ito
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Hiroaki Shimokawa
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine

Keywords: Adipose tissue, Computed tomography, Coronary spasm

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Supplementary material

2016 Volume 80 Issue 7 Pages 1653-1656

DOI https://doi.org/10.1253/circj.CJ-16-0213

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Abstract

Background:Recent studies have suggested that coronary perivascular adipose tissue (PVAT) impairs coronary vasomotion, so we examined whether PVAT is increased at the spastic coronary segment in patients with vasospastic angina (VSA).Methods and Results:PVAT volume in the left anterior descending (LAD) coronary arteries on CT coronary angiography was significantly increased in 48 VSA patients with LAD spasm compared with 18 controls (30.7±2.0 vs. 21.0±3.2 cm³, P=0.01), whereas that of total epicardial adipose tissue was comparable between the 2 groups.Conclusions:The results suggested an important role of PVAT in the pathogenesis of coronary spasm. (Circ J 2016; 80: 1653–1656)

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