Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
Imaging
Optical Coherence Tomography of De Novo Lesions and In-Stent Restenosis in Coronary Saphenous Vein Grafts (OCTOPUS Study)
Tomasz RolederElżbieta PociaskWojciech WańhaMagdalena DobrolińskaPaweł GąsiorGrzegorz SmolkaWojciech WalkowiczTomasz JadczykTomasz BochenekDariusz DudekAndrzej OchałaKatarzyna Mizia-StecZbigniew GąsiorMichał TenderaZiad A AliWojciech Wojakowski
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML

2016 Volume 80 Issue 8 Pages 1804-1811

Details
Abstract

Background:The OCTOPUS registry prospectively evaluates the procedural and long-term outcomes of saphenous vein graft (SVG) PCI. The current study assessed the morphology of de novo lesions and in-stent restenosis (ISR) in patients undergoing PCI of SVG.

Methods and Results:Optical coherence tomography (OCT) of SVG lesions in consecutive patients presenting with stable CAD and ACS was carried out. Thirty-nine patients (32 de novo and 10 ISR lesions) were included in the registry. ISR occurred in 5 BMS and 5 DES. There were no differences in the presence of plaque rupture and thrombus between de novo lesions and ISR. Lipid-rich tissue was identified in both de novo lesions and in ISR (75% vs. 50%, P=0.071) with a higher prevalence in BMS than in DES (23% vs. 7.5%; P=0.048). Calcific de novo lesions were detected in older grafts as compared with non-calcific atheromas (159±57 vs. 90±62 months after CABG, P=0.001). Heterogeneous neointima was found only in ISR (70% vs. 0, P<0.001) and was observed with similar frequency in both BMS and DES (24% vs. 30%, P=0.657). ISR was detected earlier in DES than BMS (median, 50 months; IQR, 18–96 months vs. 27 months; IQR, 13–29 months, P<0.001).

Conclusions:OCT-based characteristics of de novo and ISR lesions in SVG were similar except for heterogeneous tissue, which was observed only in ISR. (Circ J 2016; 80: 1804–1811)

Information related to the author
© 2016 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
feedback
Top