Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
Heart Failure
Demographics, Management, and In-Hospital Outcome of Hospitalized Acute Heart Failure Syndrome Patients in Contemporary Real Clinical Practice in Japan ― Observations From the Prospective, Multicenter Kyoto Congestive Heart Failure (KCHF) Registry ―
Hidenori YakuNeiko OzasaTakeshi MorimotoYasutaka InuzukaYodo TamakiErika YamamotoYusuke YoshikawaTakeshi KitaiRyoji TaniguchiMoritake IguchiMasashi KatoMamoru TakahashiToshikazu JinnaiTomoyuki IkedaKazuya NagaoTakafumi KawaiAkihiro KomasaRyusuke NishikawaYuichi KawaseTakashi MorinagaKanae SuMitsunori KawatoKenichi SasakiMamoru ToyofukuYutaka FurukawaYoshihisa NakagawaKenji AndoKazushige KadotaSatoshi ShizutaKoh OnoYukihito SatoKoichiro KuwaharaTakao KatoTakeshi Kimuraon behalf of the KCHF Study Investigators
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2018 Volume 82 Issue 11 Pages 2811-2819

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Abstract

Background: There is a scarcity of reports on the clinical characteristics and management practice in contemporary all-comer patients with acute decompensated heart failure (ADHF).

Methods and Results: The Kyoto Congestive Heart Failure (KCHF) registry is a prospective observational cohort study enrolling 4,056 consecutive patients who had hospital admission due to ADHF without any exclusion criteria between October 2014 and March 2016 in the 19 participating hospitals in Japan. Baseline characteristics, clinical presentations, management, and in-hospital outcomes were compared between heart failure (HF) with reduced left ventricular ejection fraction (LVEF; HFrEF, LVEF <40%), HF with mid-range LVEF (HFmrEF, LVEF 40–49%), and HF with preserved LVEF (HFpEF, LVEF ≥50%). Of the 4,041 patients with documented LVEF, 1,744 (43%) had HFpEF; 746 (19%), HFmrEF; and 1,551 (38%), HFrEF. The median age was 80 years (IQR, 72–86 years) in the entire population, and was higher with increasing LVEF (P<0.001). The in-hospital mortality rate was higher in the HFrEF than in the HFmrEF and HFpEF groups (9.2%, 4.8%, and 5.1%, respectively, P<0.001).

Conclusions: This registry elucidated the clinical features and clinically relevant in-hospital outcomes in contemporary consecutive patients with ADHF in real-world clinical practice in Japan. When classified by LVEF, significant differences in characteristics and in-hospital outcomes existed between patients with HFrEF, HFmrEF, and HFpEF.

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© 2018 THE JAPANESE CIRCULATION SOCIETY
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