Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Heart Failure
Association of Age at Menarche With Left Ventricular Diastolic Dysfunction in Middle-Aged Women
Seungho RyuYoosoo ChangJeong Gyu KangJidong SungJang-Young KimHyun-Suk JungKyung Eun YunChan-Won KimJuhee ChoMin-Jung KwonKye-Hyun KimHocheol ShinKi-Chul Sung
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2018 Volume 82 Issue 3 Pages 708-714

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Abstract

Background:There is sparse research on whether if early menarche is related to left ventricular (LV) diastolic dysfunction. The present study examined this relationship in Korean women.

Methods and Results:In a cross-sectional study we analyzed the records of 18,910 Korean women (≥30 years) who underwent echocardiography as part of a comprehensive health examination. Age at menarche was assessed using standardized, self-administered questionnaires. Presence of LV diastolic dysfunction was determined from the echocardiographic findings. Of the 18,910 women, 3,449 had LV diastolic dysfunction. Age at menarche was inversely associated with prevalence of LV diastolic dysfunction. In a multivariable-adjusted model, odds ratios (95% confidence interval) for LV diastolic dysfunction comparing menarche age to menarche at 15–18 years were 1.77 (1.38–2.27) for <12 years, 1.31 (1.11–1.54) for 12 years, 1.26 (1.11–1.43) for 13 years, and 1.03 (0.91–1.15) for 14 years (P for trend <0.001). Adjusting for body mass index or percent fat mass partially reduced these associations.

Conclusions:This large study found an inverse relationship between menarche age and LV diastolic dysfunction. Future prospective studies are needed to investigate potential causal relationships.

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© 2018 THE JAPANESE CIRCULATION SOCIETY
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