Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
Heart Failure
Fate of Acute Heart Failure Patients With Mid-Range Ejection Fraction
Hye Bin GwagGa Yeon LeeJin-Oh ChoiHae-Young LeeJae-Joong KimKyung-Kuk HwangShung Chull ChaeSang Hong BaekSeok-Min KangDong-Ju ChoiByung-Su YooKye Hun KimHyun-Young ParkMyeong-Chan ChoByung-Hee OhEun-Seok Jeonon behalf of the KorAHF Registry
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2018 Volume 82 Issue 8 Pages 2071-2078

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Abstract

Background:The outcomes of heart failure (HF) with mid-range ejection fraction (HFmrEF) have been rarely studied, and follow-up data on left ventricular ejection fraction (LVEF) are scarse.

Methods and Results:Patients were selected from a prospective multicenter registry of patients hospitalized for acute HF and then classified in the improved group if they exhibited %LVEF change ≥5 with follow-up LVEF ≥50%. Follow-up LVEF reported at least 90 days after discharge was used for classification. Of the 3,085 patients with acute HF, 454 were classified in the HFmrEF, and 276 had follow-up data. Of these 276 patients, 34.1% were classified in the improved group. Multivariate analysis revealed that hypertension, higher heart rate, lower serum sodium level, and maintenance therapy with β-blocker were associated with improved LVEF. The survival rate was significantly higher in the improved group than in the other groups. Young age and maintenance therapy with renin-angiotensin system blockers or aldosterone antagonists were significantly associated with better survival in HFmrEF.

Conclusions:One-third of HFmrEF patients showed improved LVEF; moreover, the survival rate in the improved group was higher than the other groups. Renin-angiotensin system blockers and aldosterone antagonists could improve the survival of HFmrEF patients.

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© 2018 THE JAPANESE CIRCULATION SOCIETY
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