Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Cardiovascular Intervention
Effect of Statin Therapy on Fibrous Cap Thickness in Coronary Plaque on Optical Coherence Tomography ― Review and Meta-Analysis ―
Yuichi OzakiHector M. Garcia-GarciaSolomon S. BeyeneAlexandre Hideo-KajitaKayode O. KukuPaul KolmRon Waksman
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML
Supplementary material

2019 Volume 83 Issue 7 Pages 1480-1488

Details
Abstract

Background:Statin therapy has been shown to result in coronary plaque regression, but the relationship between statin use and stabilization of coronary plaque has not been elucidated. We conducted a systematic review and meta-analysis to evaluate the effect of statin therapy on fibrous cap thickness (FCT) on optical coherence tomography (OCT).

Methods and Results:Nine OCT studies (6 randomized controlled trials and 3 observational studies) were enrolled with a total of 341 patients (390 lesions). Arms of the studies were grouped according to statin type and/or dose. Random effects meta-analysis was used to estimate a pooled mean change in FCT from baseline to follow-up. The overall effect mean FCT change was 67.7 µm (95% CI: 51.4–84.1, I2=95.0%, P<0.001). All statin groups had an increase in FCT, but the magnitude of the increase differed according to the statin. Two homogeneous subgroups with I2=0 were identified: mean FCT change was 27.8 µm (for subgroup atorvastatin 5 mg and rosuvastatin), and 61.9 µm (for subgroup atorvastatin 20 mg, fluvastatin 30 mg, and pitavastatin 4 mg). On meta-regression modeling, statin therapy alone explained most of the change in FCT.

Conclusions:Statin therapy induced a significant increase in FCT as assessed on OCT, independent of coronary risk factors and other medications.

Information related to the author
© 2019 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
feedback
Top