Multiple Cardiovascular Diseases or Risk Factors Increase the Severity of Coronavirus Disease 2019

Tomoyuki Yamada; Taku Ogawa; Kenta Minami; Yusuke Kusaka; Masaaki Hoshiga; Akira Ukimura; Takahide Sano; Takeshi Kitai; Taishi Yonetsu; Sho Torii; Shun Kohsaka; Shunsuke Kuroda; Koichi Node; Yuya Matsue; Shingo Matsumoto

doi:10.1253/circj.CJ-21-0684

Rapid Communications

Multiple Cardiovascular Diseases or Risk Factors Increase the Severity of Coronavirus Disease 2019

Tomoyuki Yamada, Taku Ogawa, Kenta Minami, Yusuke Kusaka, Masaaki Hoshiga, Akira Ukimura, Takahide Sano, Takeshi Kitai, Taishi Yonetsu, Sho Torii, Shun Kohsaka, Shunsuke Kuroda, Koichi Node, Yuya Matsue, Shingo Matsumoto

Author information

Tomoyuki Yamada
Infection Control Center, Osaka Medical and Pharmaceutical University Hospital [Japan]
Department of Pharmacy, Osaka Medical and Pharmaceutical University Hospital [Japan]
Taku Ogawa
Infection Control Center, Osaka Medical and Pharmaceutical University Hospital [Japan]
Department of Microbiology and Infection Control, Osaka Medical and Pharmaceutical University [Japan]
Kenta Minami
Infection Control Center, Osaka Medical and Pharmaceutical University Hospital [Japan]
Yusuke Kusaka
Infection Control Center, Osaka Medical and Pharmaceutical University Hospital [Japan]
Department of Anesthesiology, Osaka Medical and Pharmaceutical University [Japan]
Masaaki Hoshiga
Department of Cardiology, Osaka Medical and Pharmaceutical University [Japan]
Akira Ukimura
Infection Control Center, Osaka Medical and Pharmaceutical University Hospital [Japan]
Department of Cardiology, Osaka Medical and Pharmaceutical University [Japan]
Takahide Sano
Department of Cardiovascular Medicine, Toho University Graduate School of Medicine [Japan]
Takeshi Kitai
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center [Japan]
Taishi Yonetsu
Department of Interventional Cardiology, Tokyo Medical and Dental University [Japan]
Sho Torii
Department of Cardiology, Tokai University School of Medicine [Japan]
Shun Kohsaka
Department of Cardiology, Keio University School of Medicine [Japan]
Shunsuke Kuroda
Department of Cardiovascular Medicine, Cleveland Clinic [United States]
Koichi Node
Department of Cardiovascular Medicine, Saga University [Japan]
Yuya Matsue
Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine [Japan]
Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine [Japan]
Shingo Matsumoto
Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine [Japan]

Keywords: Cardiovascular disease, Cardiovascular risk factors, Coronavirus disease

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Supplementary material

2021 Volume 85 Issue 11 Pages 2111-2115

DOI https://doi.org/10.1253/circj.CJ-21-0684

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Abstract

Background:This study aimed to determine whether disease severity varied according to whether coronavirus disease 2019 (COVID-19) patients had multiple or single cardiovascular diseases and risk factors (CVDRFs).

Methods and Results:COVID-19 patients with single (n=281) or multiple (n=412) CVDRFs were included retrospectively. Multivariable logistic regression showed no significant difference in the risk of in-hospital death between groups, but patients with multiple CVDRFs had a significantly higher risk of acute respiratory distress syndrome (odds ratio: 1.75, 95% confidence interval: 1.09–2.81).

Conclusions:COVID-19 patients with multiple CVDRFs have a higher risk of complications than those with a single CDVRF.

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