Usefulness of the Slope of the Preload Recruitable Stroke Work Relationship for the Prediction of Rehospitalization After Transcatheter Mitral Edge-to-Edge Repair

Abstract

Background: Among patients with functional mitral regurgitation (FMR), responders to transcatheter mitral edge-to-edge repair (TEER) remain unclear. We investigated whether the slope of the preload recruitable stroke work relationship (M_w; calculated as stroke work / [EDV − k × EDV + {1 − k} × LV wall], where EDV is end-diastolic volume, k is a constant, and LV wall is the volume of the left ventricular wall) could predict rehospitalization in FMR patients after TEER.

Methods and Results: M_wwas calculated for 24 FMR patients using echocardiography. The median left ventricular ejection fraction was 27% and the median M_wwas 32. Over a 498-day median follow-up period, 38% of patients were rehospitalized for heart failure, and only M_whad a high area under the curve in time-dependent receiver operating characteristic analysis.

Conclusions: M_wis an effective predictor for rehospitalization in FMR patients after TEER.