Prevalence, Characteristics, and Pharmacological Strategies in Patients With Heart Failure With Supranormal Ejection Fraction　― Insights From the PARACLETE Study ―

Abstract

Background: Little is known about the recently emerging entity, heart failure with supranormal ejection fraction (HFsnEF).

Methods and Results: Subanalysis of a nationwide, prospective, observational registry that included compensated ambulatory patients with chronic HF and left ventricular ejection fraction (LVEF) >40%. Among the 4,387 patients (mean age 77 years, 43% female), 1,423 had HFsnEF. They were older, more often female, had lower natriuretic peptide levels, and exhibited smaller LV. The prescription rate of guideline-directed medical therapy was lower.

Conclusions: HFsnEF is a common and distinct phenotype characterized by a unique profile and treatment.