Symptomatic Pulmonary Regurgitation Without Right Ventricular Enlargement Accompanied by Biventricular Diastolic Dysfunction in Repaired Tetralogy of Fallot and Related Diseases

Sayuri Yamabe; Kiyomi Kayama; Yoshiro Tsuruta; Yu Kawada; Tatsuya Mizoguchi; Masashi Yokoi; Kento Mori; Tsuyoshi Ito; Kyoko Matsui; Shuichi Kitada; Toshihiko Goto; Masahiro Yasuda; Hitomi Kimura; Satoshi Koyama; Tsutomu Shinohara; Keiichi Itatani; Yoshihiro Seo

doi:10.1253/circj.CJ-25-0786

Research Letters

Symptomatic Pulmonary Regurgitation Without Right Ventricular Enlargement Accompanied by Biventricular Diastolic Dysfunction in Repaired Tetralogy of Fallot and Related Diseases

Sayuri Yamabe , Kiyomi Kayama, Yoshiro Tsuruta, Yu Kawada, Tatsuya Mizoguchi, Masashi Yokoi, Kento Mori, Tsuyoshi Ito, Kyoko Matsui, Shuichi Kitada, Toshihiko Goto, Masahiro Yasuda, Hitomi Kimura, Satoshi Koyama, Tsutomu Shinohara, Keiichi Itatani, Yoshihiro Seo

Author information

Sayuri Yamabe Corresponding author
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Kiyomi Kayama
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Yoshiro Tsuruta
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Yu Kawada
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Tatsuya Mizoguchi
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Masashi Yokoi
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Kento Mori
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Tsuyoshi Ito
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Kyoko Matsui
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Shuichi Kitada
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Toshihiko Goto
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Masahiro Yasuda
Department of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Hitomi Kimura
Department of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Satoshi Koyama
Department of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Tsutomu Shinohara
Department of Pediatrics and Neonatology, Nagoya City University, Graduate School of Medical Sciences [Japan]
Keiichi Itatani
Department of Cardiovascular Surgery, Nagoya City University, Graduate School of Medical Sciences [Japan]
Yoshihiro Seo
Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences [Japan]

Keywords: Diastolic dysfunction, Pulmonary regurgitation, Tetralogy of Fallot

JOURNAL OPEN ACCESS FULL-TEXT HTML

2026 Volume 90 Issue 9 Pages 1299-1301

DOI https://doi.org/10.1253/circj.CJ-25-0786

Editorial (90-9 pp. 1302-1303)

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Abstract

Background: In repaired tetralogy of Fallot (TOF) and related diseases, reoperation for pulmonary regurgitation (PR) may be delayed unless marked right ventricular (RV) enlargement is present.

Methods and Results: 32 patients with significant PR post-repair underwent catheterization and 4D flow MRI for reoperation evaluation. The Non-severe RV Dilation group (n=20) did not meet the surgical volume criteria, whereas the Severe RV Dilation group (n=12) did. The Non-severe RV Dilation group had higher biventricular filling pressures. The RV-Energy loss index in both groups was high.

Conclusions: Diastolic dysfunction could serve as a therapeutic target in PR patients with heterogeneous etiologies.

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