Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Association Between Circulating Monocytes and Coronary Plaque Progression in Patients With Acute Myocardial Infarction
Naoki NozawaKiyoshi HibiMitsuaki EndoTeruyasu SuganoToshiaki EbinaMasami KosugeKengo TsukaharaJun OkudaSatoshi UmemuraKazuo Kimura
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JOURNALS FREE ACCESS Advance online publication

Article ID: CJ-09-0779


Background: Monocytes and macrophages have been shown to play major roles in the progression of atherosclerosis. This study examined whether the circulating monocyte count can be used to predict coronary plaque progression of non-culprit intermediate lesions in acute myocardial infarction (AMI). Methods and Results: Intravascular ultrasound findings of non-culprit intermediate plaque in 90 patients were analyzed in the acute phase and at a 7-month follow up. A higher peak monocyte count after AMI was associated with a greater plaque volume change (r=0.32, P=0.002). Multivariate analysis showed that a peak monocyte count of ≥800 /mm3 was an independent predictor of plaque progression (odds ratio 5.02, P=0.005). High monocyte (≥800 /mm3) at baseline had a higher monocyte count at 7-month follow up than did those with a lower count (368±109 vs 263±64 /mm3, P<0.0001). Moreover, the monocyte count at the 7-month follow up was also associated with plaque volume change (r=0.29, P=0.006). Conclusions: The results suggest that circulating monocytes play an important role in the progression of coronary plaque in AMI and that the peak monocyte count during hospitalization might be a predictor of plaque progression.

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