Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Pathophysiological Roles of NADPH Oxidase/Nox Family Proteins in the Vascular System
– Review and Perspective –
Tetsuro AgoJunya KurodaMasahiro KamouchiJunichi SadoshimaTakanari Kitazono
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JOURNALS FREE ACCESS Advance online publication

Article ID: CJ-11-0388

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Abstract

It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

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© 2011 THE JAPANESE CIRCULATION SOCIETY
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