Pathophysiological Roles of NADPH Oxidase/Nox Family Proteins in the Vascular System – Review and Perspective –

Tetsuro Ago; Junya Kuroda; Masahiro Kamouchi; Junichi Sadoshima; Takanari Kitazono

doi:10.1253/circj.CJ-11-0388

This article has now been updated. Please use the final version.

Pathophysiological Roles of NADPH Oxidase/Nox Family Proteins in the Vascular System

– Review and Perspective –

Tetsuro Ago, Junya Kuroda, Masahiro Kamouchi, Junichi Sadoshima, Takanari Kitazono

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Keywords: NADPH oxidase/Nox, Reactive oxygen species, Vascular diseases

JOURNAL FREE ACCESS Advance online publication

Article ID: CJ-11-0388

DOI https://doi.org/10.1253/circj.CJ-11-0388

The final version of this article is now available: Vol. 75 (2011) , No. 8 p.1791

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Abstract

It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

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