Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843

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Transcriptome Complexity in Cardiac Development and Diseases
– An Expanding Universe Between Genome and Phenome –
Chen GaoYibin Wang
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JOURNAL FREE ACCESS Advance online publication

Article ID: CJ-14-0412

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Abstract
With the advancement of transcriptome profiling by micro-arrays and high-throughput RNA-sequencing, transcriptome complexity and its dynamics are revealed at different levels in cardiovascular development and diseases. In this review, we will highlight the recent progress in our knowledge of cardiovascular transcriptome complexity contributed by RNA splicing, RNA editing and noncoding RNAs. The emerging importance of many of these previously under-explored aspects of gene regulation in cardiovascular development and pathology will be discussed.
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© 2014 THE JAPANESE CIRCULATION SOCIETY
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