Proposed Cutoff Value of Brachial-Ankle Pulse Wave Velocity for the Management of Hypertension

Toshiaki Ohkuma; Hirofumi Tomiyama; Toshiharu Ninomiya; Kazuomi Kario; Satoshi Hoshide; Yoshikuni Kita; Toyoshi Inoguchi; Yasutaka Maeda; Katsuhiko Kohara; Yasuharu Tabara; Motoyuki Nakamura; Takayoshi Ohkubo; Hirotaka Watada; Masanori Munakata; Mitsuru Ohishi; Norihisa Ito; Michinari Nakamura; Tetsuo Shoji; Charalambos Vlachopoulos; Akira Yamashina; on behalf of the Collaborative Group for Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies (J-BAVEL)

doi:10.1253/circj.CJ-17-0636

This article has now been updated. Please use the final version.

Proposed Cutoff Value of Brachial-Ankle Pulse Wave Velocity for the Management of Hypertension

Toshiaki Ohkuma, Hirofumi Tomiyama, Toshiharu Ninomiya, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Akira Yamashina, on behalf of the Collaborative Group for Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies (J-BAVEL)

Author information

Toshiaki Ohkuma
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
Hirofumi Tomiyama
Department of Cardiology, Tokyo Medical University
Toshiharu Ninomiya
Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University
Kazuomi Kario
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine
Satoshi Hoshide
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine
Yoshikuni Kita
Faculty of Nursing Science, Tsuruga Nursing University
Toyoshi Inoguchi
Innovation Center for Medical Redox Navigation, Kyushu University
Yasutaka Maeda
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Katsuhiko Kohara
Department of Regional Resource Management, Faculty of Collaborative Regional Innovation, Ehime University
Yasuharu Tabara
Center for Genomic Medicine, Kyoto University Graduate School of Medicine
Motoyuki Nakamura
Department of Internal Medicine, Iwate Medical University
Takayoshi Ohkubo
Department of Hygiene and Public Health, Teikyo University School of Medicine
Hirotaka Watada
Departments of Metabolism & Endocrinology, Juntendo University, Graduate School of Medicine
Masanori Munakata
Research Center for Lifestyle-related Disease, Tohoku Rosai Hospital
Mitsuru Ohishi
Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University
Norihisa Ito
Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine
Michinari Nakamura
Cardiovascular Institute Japan
Tetsuo Shoji
Department of Vascular Medicine, Osaka City University Graduate School of Medicine
Charalambos Vlachopoulos
Hypertension and Cardiometabolic Unit, (1st) Department of Cardiology, Athens Medical School, Hippokration Hospital
Akira Yamashina
Department of Cardiology, Tokyo Medical University
on behalf of the Collaborative Group for Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies (J-BAVEL)

Keywords: Arterial stiffness, Hypertension, Pulse wave velocity

JOURNAL FREE ACCESS FULL-TEXT HTML Advance online publication
Supplementary material

Article ID: CJ-17-0636

DOI https://doi.org/10.1253/circj.CJ-17-0636

The final version of this article is now available: Vol. 81 (2017), No. 10 pp. 1540-1542

Details

Abstract

Background:The optimal cutoff values of the brachial-ankle pulse wave velocity (baPWV) for predicting cardiovascular disease (CVD) were examined in patients with hypertension.

Methods and Results:A total of 7,656 participants were followed prospectively. The hazard ratio for the development of CVD increased significantly as the baPWV increased, independent of conventional risk factors. The receiver-operating characteristic curve analysis showed that the optimal cutoff values for predicting CVD was 18.3 m/s. This cutoff value significantly predicted THE incidence of CVD.

Conclusions:The present analysis suggests that the optimal cutoff value for CVD in patients with hypertension is 18.3 m/s.

Corresponding author

Register with J-STAGE for free!