MitraClip in Patients With Mitral Regurgitation and Left Ventricular Ejection Fraction <30%　― Potential Implications for the Treatment of Patients in Japan ―

Hidehiro Kaneko; Mitsunobu Kitamura; Michael Neuss; Maki Okamoto; Tobias Schmidt; Hannes Alessandrini; Karl-Heinz Kuck; Issei Komuro; Christian Frerker; Christian Butter

doi:10.1253/circj.CJ-18-0536

This article has now been updated. Please use the final version.

MitraClip in Patients With Mitral Regurgitation and Left Ventricular Ejection Fraction <30%　― Potential Implications for the Treatment of Patients in Japan ―

Hidehiro Kaneko, Mitsunobu Kitamura, Michael Neuss, Maki Okamoto, Tobias Schmidt, Hannes Alessandrini, Karl-Heinz Kuck, Issei Komuro, Christian Frerker, Christian Butter

Author information

Hidehiro Kaneko
Heart Center Brandenburg
Department of Cardiovascular Medicine, The University of Tokyo
Department of Advanced Cardiology, The University of Tokyo
Mitsunobu Kitamura
Department of Cardiology, Asklepios Klinik St. Georg
Michael Neuss
Heart Center Brandenburg
Maki Okamoto
Heart Center Brandenburg
Tobias Schmidt
Department of Cardiology, Asklepios Klinik St. Georg
Hannes Alessandrini
Department of Cardiology, Asklepios Klinik St. Georg
Karl-Heinz Kuck
Department of Cardiology, Asklepios Klinik St. Georg
Issei Komuro
Department of Cardiovascular Medicine, The University of Tokyo
Christian Frerker
Department of Cardiology, Asklepios Klinik St. Georg
Christian Butter
Heart Center Brandenburg

Keywords: Left ventricular ejection fraction, MitraClip, Mitral regurgitation

JOURNAL FREE ACCESS FULL-TEXT HTML Advance online publication

Article ID: CJ-18-0536

DOI https://doi.org/10.1253/circj.CJ-18-0536

The final version of this article is now available: Vol. 82 (2018), No. 10 pp. 2672-2675

Details

Abstract

Background:The effect of the unique Japanese indication for MitraClip based on left ventricular ejection fraction (LVEF) is unclear.

Methods and Results:We analyzed 874 patients who underwent MitraClip because of mitral regurgitation (MR) and compared the characteristics and outcomes between patients with LVEF <30% and ≥30%. Patients with LVEF ≤30% accounted for 33% of the study population and had a higher prevalence of functional MR. Severity of MR after MitraClip was comparable, and LVEF <30% did not independently affect survival.

Conclusions:Japanese unique indication based on LVEF may exclude one third of patients who were treated with MitraClip in Europe.

Corresponding author

Register with J-STAGE for free!