Unexpectedly High Prevalence of Coronary Spastic Angina in Patients With Anderson-Fabry Disease

Yuya Kitani; Naoki Nakagawa; Naka Sakamoto; Toshiharu Takeuchi; Fumihiko Takahashi; Ken Momosaki; Kimitoshi Nakamura; Fumio Endo; Hiroki Maruyama; Naoyuki Hasebe

doi:10.1253/circj.CJ-18-0734

This article has now been updated. Please use the final version.

Unexpectedly High Prevalence of Coronary Spastic Angina in Patients With Anderson-Fabry Disease

Yuya Kitani, Naoki Nakagawa, Naka Sakamoto, Toshiharu Takeuchi, Fumihiko Takahashi, Ken Momosaki, Kimitoshi Nakamura, Fumio Endo, Hiroki Maruyama, Naoyuki Hasebe

Author information

Yuya Kitani
Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University
Naoki Nakagawa
Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University
Naka Sakamoto
Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University
Toshiharu Takeuchi
Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University
Fumihiko Takahashi
Department of Cardiology, Rumoi City Hospital
Ken Momosaki
Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University
Kimitoshi Nakamura
Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University
Fumio Endo
Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University
Hiroki Maruyama
Department of Clinical Nephroscience, Niigata University Graduate School of Medical and Dental Sciences
Naoyuki Hasebe
Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University

Keywords: Acetylcholine-induced provocation test, Anderson-Fabry disease, Coronary spastic angina

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Supplementary material

Article ID: CJ-18-0734

DOI https://doi.org/10.1253/circj.CJ-18-0734

Article (83-2 pp. 481-484)

Details

Abstract

Background: Although we and others have reported cases of patients with Anderson-Fabry disease (AFD) complicated by coronary spastic angina (CSA), the prevalence of CSA in these patients remains unknown.

Methods and Results: We performed the acetylcholine-induced provocation test, according to the Japanese guidelines for the diagnosis and treatment of patients with CSA, in 9 consecutive patients having 5 independent AFD pedigrees. Coronary spasms were provoked in conjunction with symptoms and ECG ischemic changes in 8 of 9 (89%) patients with AFD.

Conclusions: We found an unexpectedly high prevalence of CSA in patients with AFD.

Corresponding author

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