Predictive Value of CHADS₂, CHA₂DS₂-VASc and R₂-CHADS₂ Scores for Short- and Long-Term Major Adverse Cardiac Events in Non-ST-Segment Elevation Myocardial Infarction

Abstract

Background: Non-ST-elevation myocardial infarction (NSTEMI) carries a poor prognosis, and accurately prognostication has significant clinical importance. In this study, we analyzed the predictive value of the CHADS₂, CHA₂DS₂-VASc, and R₂-CHADS₂scores for major adverse cardiac events (MACE) following percutaneous coronary intervention (PCI) in patients with NSTEMI using data from a prospective multicenter registry.

Methods and Results: The registry included 440 consecutive patients with NSTEMI and coronary artery disease who underwent successful PCI. Patients were clinically followed for up to 3 years or until the occurrence of MACE. MACE was defined as a composite of all-cause death and nonfatal MI. During the follow-up period, 55 patients (12.5%) experienced MACE. Risk analysis of MACE occurrence, adjusted for the multivariable model, demonstrated a significant increase in risk with higher CHADS₂, CHA₂DS₂-VASc, and R₂-CHADS₂scores. Kaplan-Meier analysis showed a higher incidence of MACE in patients with higher CHADS₂, CHA₂DS₂-VASc, and R₂-CHADS₂scores, both in the short- and long-term periods.

Conclusions: Patients with NSTEMI and higher CHADS₂, CHA₂DS₂-VASc, and R₂-CHADS₂scores displayed a greater incidence of MACE.