Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants for Japanese Patients With Venous Thromboembolism　― The Primary Results From the KUROSIO Study ―

Norikazu Yamada; Satoshi Tamaru; Michihisa Umetsu; Kenichi Tsujita; Masato Nakamura; Atsuyuki Watanabe; Mitsuru Yuzaki; Yuki Nishimura; Toru Ogura; Takeshi Yamamoto; Hirono Satokawa; Toru Obayashi; Mashio Nakamura; on behalf of KUROSIO Study Investigators

doi:10.1253/circj.CJ-23-0954

This article has now been updated. Please use the final version.

Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants for Japanese Patients With Venous Thromboembolism　― The Primary Results From the KUROSIO Study ―

Norikazu Yamada , Satoshi Tamaru, Michihisa Umetsu, Kenichi Tsujita, Masato Nakamura, Atsuyuki Watanabe, Mitsuru Yuzaki, Yuki Nishimura, Toru Ogura, Takeshi Yamamoto, Hirono Satokawa, Toru Obayashi, Mashio Nakamura, on behalf of KUROSIO Study Investigators

Author information

Norikazu Yamada Corresponding author
Department of Cardiology, Kuwana City Medical Center [Japan]
Satoshi Tamaru
Clinical Research Support Center, Mie University Hospital [Japan]
Michihisa Umetsu
Division of Vascular Surgery, Department of Surgery, Tohoku University Hospital [Japan]
Kenichi Tsujita
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University [Japan]
Masato Nakamura
Department of Cardiology, Ohashi Hospital, Toho University [Japan]
Atsuyuki Watanabe
Department of Cardiology, National Hospital Organization Okayama Medical Center [Japan]
Mitsuru Yuzaki
Department of Cardiovascular Surgery, Wakayama Saiseikai Hospital [Japan]
Yuki Nishimura
Clinical Research Support Center, Mie University Hospital [Japan]
Toru Ogura
Clinical Research Support Center, Mie University Hospital [Japan]
Takeshi Yamamoto
Division of Cardiovascular Intensive Care, Nippon Medical School Hospital [Japan]
Hirono Satokawa
Department of Cardiovascular Surgery, Fukushima Medical University Hospital [Japan]
Toru Obayashi
Faculty of Health Science, Gunma Paz University [Japan]
Mashio Nakamura
Hidamarinooka Nakamura Medical Clinic [Japan]
on behalf of KUROSIO Study Investigators

Keywords: Deep vein thrombosis, Direct oral anticoagulants, Pulmonary thromboembolism, Venous thromboembolism

JOURNAL OPEN ACCESS FULL-TEXT HTML Advance online publication

Article ID: CJ-23-0954

DOI https://doi.org/10.1253/circj.CJ-23-0954

The final version of this article is now available: Vol. 88 (2024), No. 10 pp. 1672-1678

Details

Abstract

Background: Direct oral anticoagulants (DOACs) are recommended as the first-choice anticoagulation therapy in the acute phase of venous thromboembolism (VTE). However, there is limited real-world data for Japanese VTE patients.

Methods and Results: The KUROSIO study (UMIN000023747) was a prospective long-term observational study comprising 1,017 patients with concurrent acute symptomatic pulmonary thromboembolism and proximal deep vein thrombosis (DVT) or isolated calf DVT initially treated with DOACs. After excluding 24 patients, 993 (mean age, 66.3±15.1 years; 58.6% females) were analyzed. The incidences of recurrent symptomatic VTE and major bleeding for up to 52 weeks after diagnosis were 3.2% and 2.2%, respectively. Multivariate analyses revealed chemotherapy and anemia as significant risk factors associated with recurrent symptomatic VTE and major bleeding, respectively.

Conclusions: The efficacy and safety of DOACs in Japanese patients with VTE were determined in this real-world observational study.

Corresponding author

Register with J-STAGE for free!