Sex-Specific Association Between Calcium-Channel Blocker Use and B-Type Natriuretic Peptide Levels in Elderly Hypertensive Patients With Heart Failure With Preserved Ejection Fraction

Eisaku Harada; Toshihiro Yamada; Yuji Mizuno; Yuichiro Arima; Koichi Kikuta; Hirofumi Yasue

doi:10.1253/circj.CJ-25-0404

This article has now been updated. Please use the final version.

Sex-Specific Association Between Calcium-Channel Blocker Use and B-Type Natriuretic Peptide Levels in Elderly Hypertensive Patients With Heart Failure With Preserved Ejection Fraction

Eisaku Harada, Toshihiro Yamada, Yuji Mizuno, Yuichiro Arima, Koichi Kikuta, Hirofumi Yasue

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Keywords: Calcium-channel blockers, Heart failure with preserved ejection fraction, Sex differences

JOURNAL OPEN ACCESS FULL-TEXT HTML Advance online publication

Article ID: CJ-25-0404

DOI https://doi.org/10.1253/circj.CJ-25-0404

The final version of this article is now available: Vol. 89 (2025), No. 10 pp. 1719-1721

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Abstract

Background: The effects of calcium-channel blockers (CCBs) in heart failure with preserved ejection fraction (HFpEF), particularly by sex, remain unclear.

Methods and Results: We retrospectively analyzed 412 elderly hypertensive patients with HFpEF (308 women, 104 men). Female CCB users had significantly lower B-type natriuretic peptide (BNP) levels. Multivariable regression showed that CCB use was independently associated with lower BNP, higher EF, and lower tricuspid regurgitation pressure gradient in women, but not in men.

Conclusions: CCB use, particularly amlodipine, may be associated with sex-specific hemodynamic benefits in hypertensive elderly women with HFpEF, independent of blood pressure control.

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