2026 Volume 8 Issue 2 Pages 324-332
Background: Lower extremity artery disease (LEAD) is a common disease associated with a higher risk of amputation and death. The Geriatric Nutritional Risk Index (GNRI) is a useful marker for assessing nutritional status; however, its relationship with outcomes in patients with LEAD following endovascular therapy (EVT) remains unclear.
Methods and Results: This study included 127 patients who underwent initial EVT between April 2010 and December 2022. Patients were divided into 2 groups based on a GNRI score of 92. The primary endpoint was all-cause mortality; the secondary endpoint was major amputation after EVT. The median follow-up period was 47.5 months (interquartile range 34.0–61.8 months). All-cause mortality and major amputation were significantly higher in the group with a GNRI score <92 (log-rank P<0.01). GNRI was independently associated with all-cause mortality after EVT (hazard ratio 0.95 per 1-unit increase in GNRI; 95% confidence interval 0.92–0.97; P<0.01). In addition, in the claudication group, all-cause mortality and major amputation were significantly higher in the group with a GNRI score <92 (log-rank P=0.01 and P=0.02, respectively).
Conclusions: All-cause mortality and major amputation after EVT were significantly higher in the patients with a GNRI score <92 overall, as well as in the claudication group. These findings highlight the importance of addressing nutritional status in the early stages of LEAD to improve clinical outcomes.
