Comparison of Landiolol and Verapamil for Postoperative Atrial Fibrillation　― A Prospective Randomized Study ―

Abstract

Background: Postoperative atrial fibrillation (POAF) after cardiac surgery requires prompt intervention. We compared landiolol with verapamil for POAF treatment.

Methods and Results: This randomized trial enrolled 179 patients; 45 developed POAF. Landiolol achieved higher sinus rhythm conversion at 8 h (73.3% vs 16.7%; P=0.0016), but not at 12 h. No differences were observed in recurrence, adverse events, or intensive care unit stay.

Conclusions: Landiolol facilitates earlier rhythm conversion without clear short-term clinical benefit.