Effects of Structural Modification of Calcium Spirulan, a Sulfated Polysaccharide from Spirulina Platensis, on Antiviral Activity

Jung-Bum LEE; Preeprame SRISOMPORN; Kyoko HAYASHI; Tomoyasu TANAKA; Ushio SANKAWA; Toshimitsu HAYASHI

doi:10.1248/cpb.49.108

Notes

Effects of Structural Modification of Calcium Spirulan, a Sulfated Polysaccharide from Spirulina Platensis, on Antiviral Activity

Jung-Bum LEE, Preeprame SRISOMPORN, Kyoko HAYASHI, Tomoyasu TANAKA, Ushio SANKAWA, Toshimitsu HAYASHI

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Keywords: calcium spirulan, sulfated polysaccharide, antiviral activity, HSV-1, metal cation, depolymerization

JOURNAL FREE ACCESS

2001 Volume 49 Issue 1 Pages 108-110

DOI https://doi.org/10.1248/cpb.49.108

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Abstract

Calcium ion binding with the anionic part of a molecule was replaced with various metal cations and their inhibitory effects on the replication of herpes simplex virus type 1 were evaluated. Replacement of calcium ion with sodium and potassium ions maintained the antiviral activity while divalent and trivalent metal cations reduced the activity. Depolymerization of sodium spirulan with hydrogen peroxide decreased in antiviral activity as its molecular weight decreased.

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