Two New Pyrrolidine Alkaloids, Radicamines A and B, as Inhibitors of α-Glucosidase from Lobelia chinensis LOUR.

Makio SHIBANO; Daisuke TSUKAMOTO; Atsuko MASUDA; Yasuko TANAKA; Genjiro KUSANO

doi:10.1248/cpb.49.1362

Notes

Two New Pyrrolidine Alkaloids, Radicamines A and B, as Inhibitors of α-Glucosidase from Lobelia chinensis LOUR.

Makio SHIBANO, Daisuke TSUKAMOTO, Atsuko MASUDA, Yasuko TANAKA, Genjiro KUSANO

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Keywords: pyrrolidine alkaloid, α-glucosidase inhibitor, Lobelia chinensis, Campanulaceae, radicamine A, radicamine B

JOURNAL FREE ACCESS

2001 Volume 49 Issue 10 Pages 1362-1365

DOI https://doi.org/10.1248/cpb.49.1362

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Abstract

Two new pyrrolidine alkaloids, radicamines A and B were isolated as inhibitors of α-glucosidase from Lobelia chinensis LOUR. (Campanulaceae). Radicamines A and B were formulated as (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(3-hydroxy-4-methoxyphenyl)-pyrrolidine (1) and (2S,3S,4S,5S)-2-hydroxymethyl-3,4-dihydroxy-5-(4-hydroxyphenyl)-pyrrolidine (2) on the basis of spectroscopic analyses and chemical methods.

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