Studies on the Constituents of Broussonetia Species X. Six New Alkaloids from Broussonetia kazinoki SIEB.

Abstract

Six new alkaloids, broussonetines W,X,M₁,U₁,J₁, and J₂ (1—6) were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae) as minor constituents. They were formulated as (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[7-(cyclohexy-2-on-1(6)-enyl)heptyl]pyrrolidine (1), (2R,3S,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[7-(cyclohexy-2-on-1(6)-enyl)heptyl]pyrrolidine-4-O-β-D-glucopyranoside (2), (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(9R)-9,13-dihydroxytridecyl]pyrrolidine (3), (2S,3S,4S)-2-hydroxymethyl-3,4-dihydroxy-5-(10-oxo-13-hydroxytridecyl)-5-pyrroline (4), (2R)-2-{(1S,2S)-1,2-dihydroxy-8-[(2R,3R,4R,5R)-5-(2-hydroxymethyl-3,4-dihydroxy-1-acetylpyrrolidinyl)]octyl}piperidine (5), (2R)-2-{(1S,2S)-1,2-dihydroxy-8-[(2R,3R,4R,5R)-5-(2-hydroxymethyl-3,4-dihydroxypyrrolidinyl)]octyl}piperidine (6).