Urinary Metabolites of Genistein Administered Orally to Rats

Takaaki YASUDA; Joji UEDA; Keisuke OHSAWA

doi:10.1248/cpb.49.1495

Notes

Urinary Metabolites of Genistein Administered Orally to Rats

Takaaki YASUDA, Joji UEDA, Keisuke OHSAWA

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Keywords: genistein, urinary metabolite, 4',5,7-trihydroxyisoflavanone, 4',7-dihydroxyisoflavan, equol, p-ethylphenol

JOURNAL FREE ACCESS

2001 Volume 49 Issue 11 Pages 1495-1497

DOI https://doi.org/10.1248/cpb.49.1495

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Abstract

In a study on the metabolism of flavonoids, the isoflavone genistein was administered orally to rats. Urine samples were collected and treated with β-glucuronidase and arylsulfatase. Genistein and its metabolites, 4',5,7-trihydroxyisoflavanone (M1), 4',7-dihydroxyisoflavan (M2), and p-ethylphenol (M3) were isolated from the urine following treatment with enzymes. The structures of M1, M2, and M3 were determined on the basis of chemical and spectral data.

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