Phosphodiesterase 4 Isoenzyme Inhibitory Activity of 3-Phenylxanthines and 4-Phenyl[i]condensed-purines

Hirokazu SUZUKI; Hiroyuki SAWANISHI; Kenji YAMAMOTO; Koichi YOKOGAWA; Ken-ichi MIYAMOTO

doi:10.1248/cpb.49.188

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Phosphodiesterase 4 Isoenzyme Inhibitory Activity of 3-Phenylxanthines and 4-Phenyl[i]condensed-purines

Hirokazu SUZUKI, Hiroyuki SAWANISHI, Kenji YAMAMOTO, Koichi YOKOGAWA, Ken-ichi MIYAMOTO

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Keywords: phosphodiesterase 4 inhibitor, 3-phenylxanthine, 4-phenyl[i]condensed-purine

JOURNAL FREE ACCESS

2001 Volume 49 Issue 2 Pages 188-191

DOI https://doi.org/10.1248/cpb.49.188

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Abstract

On the basis of our study on the structure-activity relationships of 1, 3, 7-alkylxanthines and condensed-purines on cAMP-phosphodiesterase 4 (PDE 4) isoenzyme inhibitor, we investigated the synthesis and the inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-purine derivatives. Xanthines and condensed-purines with the phenyl group exhibited potent and selective PDE 4 inhibitory activity.

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