Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix
Sam Sik KANGJu Sun KIMKun Ho SONHyun Pyo KIMHyeun Wook CHANG
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2001 Volume 49 Issue 3 Pages 321-323

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Abstract

A mixture of cerebrosides, called poke-weed cerebrosides, was purified from Phytolaccae Radix (Phytolaccaceae) and characterized as 1-O-β-D-glucopyranosides of phytosphingosine type ceramides comprised of a common long chain base (2S, 3S, 4R, 8Z)-2-amino-8-octadecene-1, 3, 4-triol and fatty acids. The fatty acyl chain of ceramide moieties was determined as (2R)-2-hydroxypentacosanoic acid, (2R)-2-hydroxylignoceric acid, (2R)-2-hydroxytricosanoic acid, (2R)-2-hydroxybehenic acid, (2R)-2-hydroxypalmitic acid, and palmitic acid. The poke-weed cerebroside inhibited the cyclooxygenase-2 dependent phase of prostaglandin D2 generation in bone marrow-derived mast cells in a concentration dependent manner with an IC50 of 6.2 μg/ml.

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© 2001 The Pharmaceutical Society of Japan
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