Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Synthesis of New Fused Pyrimidines by Isocyanate and Isothiocyanate
A.Z.M. Shaifullah CHOWDHURY, Yasuyuki SHIBATA
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Keywords: fused pyrimidine, urethane, displacement reaction, isothiocyanate, isocyanate, o-aminonitrile or ester compound
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2001 Volume 49 Issue 4 Pages 391-395

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Abstract
o-Aminonitrile or o-aminoester compounds were cyclized to fused pyrimidines by reacting with ethyl iso(thio)cyanatoacetate in pyridine, and then were methylated, halogenated and subsequently displaced by the amines studied.
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© 2001 The Pharmaceutical Society of Japan
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