Amino Acids and Peptides. XXXVIII. Facile Synthesis of Laminin-Related Peptide-Poly(Ethylene Glycol) Hybrids by the Solid Phase Method

Mitsuko MAEDA; Haruhiko KAMADA; Keiko HOJO; Yoko YAMAMOTO; Shinsaku NAKAGAWA; Timothy J. SMITH; Tadanori MAYUMI; Koichi KAWASAKI

doi:10.1248/cpb.49.488

Notes

Amino Acids and Peptides. XXXVIII. Facile Synthesis of Laminin-Related Peptide-Poly(Ethylene Glycol) Hybrids by the Solid Phase Method

Mitsuko MAEDA, Haruhiko KAMADA, Keiko HOJO, Yoko YAMAMOTO, Shinsaku NAKAGAWA, Timothy J. SMITH, Tadanori MAYUMI, Koichi KAWASAKI

著者情報

キーワード: poly(ethylene glycol), peptide-poly(ethylene glycol) hybrid, laminin, antimetastatic peptide, peptide synthesis

ジャーナルフリー

2001 年 49 巻 4 号 p. 488-491

DOI https://doi.org/10.1248/cpb.49.488

詳細

抄録

Poly(ethylene glycol) (PEG) has been studied as a drug-carrier for proteins, but not for small peptides. Laminin, a cell adhesive protein, has Tyr-Ile-Gly-Ser-Arg (YIGSR) sequence and peptides containing this sequence inhibit experimental metastasis. We have studied PEG hybrids of YIGSR and other small laminin-related peptides. In a previous paper, we reported preparation of YIGSR-PEG hybrids by combination of the solid phase method and the solution method, but the synthetic procedure was problematic. Here we report a facile synthesis of PEG hybrids of YIGSR (PEG-YIGSR, YIGSR-PEG, PEG-YIGSR-PEG) by the solid phase method.

責任著者(Corresponding author)

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