New Hemisynthetic Manoyl Oxide Derivatives with Antimicrobial Activity

Eleftherios KALPOUTZAKIS; Nektarios ALIGIANNIS; Sofia MITAKU; Ioanna CHINOU; Catherine CHARVALA; Alexios-Leandros SKALTSOUNIS

doi:10.1248/cpb.49.814

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New Hemisynthetic Manoyl Oxide Derivatives with Antimicrobial Activity

Eleftherios KALPOUTZAKIS, Nektarios ALIGIANNIS, Sofia MITAKU, Ioanna CHINOU, Catherine CHARVALA, Alexios-Leandros SKALTSOUNIS

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Keywords: labdane-type diterpene, antimicrobial activity, manoyl oxide, Cistus creticus

JOURNAL FREE ACCESS

2001 Volume 49 Issue 7 Pages 814-817

DOI https://doi.org/10.1248/cpb.49.814

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Abstract

The synthesis and antimicrobial activity of ten labdane-type diterpenes derived from ent-3-β-hydroxy-13-epi-manoyl oxide (ribenol) is reported. The chloroethyl carbamidic ester 9 showed the strongest antimicrobial activity against all the tested gram (+), gram (−) bacteria and pathogenic fungi. Moreover, the glycoside 11 exhibited an interesting activity against the three tested fungi.

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