Inhibitory Effects on HIV-1 Protease of Tri-p-coumaroylspermidine from Artemisia caruifolia and Related Amides

Chao-Mei MA; Norio NAKAMURA; Masao HATTORI

doi:10.1248/cpb.49.915

Notes

Inhibitory Effects on HIV-1 Protease of Tri-p-coumaroylspermidine from Artemisia caruifolia and Related Amides

Chao-Mei MA, Norio NAKAMURA, Masao HATTORI

著者情報

キーワード: Artemisia caruifolia, tri-p-coumaroylspermidine, tetra-p-coumaroylspermine, penta-p-coumaroyltetraethylenepentamine, dicaffeoylquinic acid, human immunodeficiency virus type 1 protease inhibitor

ジャーナルフリー

2001 年 49 巻 7 号 p. 915-917

DOI https://doi.org/10.1248/cpb.49.915

詳細

抄録

From a methanol extract of Artemisia caruifolia, which showed a moderate inhibitory activity on HIV-1 protease in a preliminary screening, N¹, N⁵, N¹⁰-tri-p-coumaroylspermidine and three dicaffeoylquinic acids were isolated. The former compound was found to appreciably inhibit HIV-1 protease. Of related amides which were chemically synthesized, N¹, N⁵, N¹⁰, N¹⁴-tetra-p-coumaroylspermine and N¹, N⁴, N⁷, N¹⁰, N¹³-penta-p-coumaroyltetraethylenepentamine inhibited HIV-1 protease more potently than N¹, N⁵, N¹⁰-tri-p-coumaroylspermidine.

責任著者(Corresponding author)

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