Correlation with Redox Potentials and Inhibitory Effects on Epstein-Barr Virus Activation of Azaanthraquinones

Junko KOYAMA; Izumi MORITA; Kiyoshi TAGAHARA; Toshiyuki OSAKAI; Hiroki HOTTA; Mou Xiao YANG; Teruo MUKAINAKA; Hoyoku NISHINO; Harukuni TOKUDA

doi:10.1248/cpb.49.1214

Notes

Correlation with Redox Potentials and Inhibitory Effects on Epstein-Barr Virus Activation of Azaanthraquinones

Junko KOYAMA, Izumi MORITA, Kiyoshi TAGAHARA, Toshiyuki OSAKAI, Hiroki HOTTA, Mou Xiao YANG, Teruo MUKAINAKA, Hoyoku NISHINO, Harukuni TOKUDA

著者情報

Junko KOYAMA
Kobe Pharmaceutical University
Izumi MORITA
Kobe Pharmaceutical University
Kiyoshi TAGAHARA
Kobe Pharmaceutical University
Toshiyuki OSAKAI
Department of Chemistry, Faculty of Science, Kobe University
Hiroki HOTTA
Department of Chemistry, Faculty of Science, Kobe University
Mou Xiao YANG
Department of Biochemistry, Kyoto Prefectural University of Medicine
Teruo MUKAINAKA
Department of Biochemistry, Kyoto Prefectural University of Medicine
Hoyoku NISHINO
Department of Biochemistry, Kyoto Prefectural University of Medicine
Harukuni TOKUDA
Department of Biochemistry, Kyoto Prefectural University of Medicine

キーワード: azaanthraquinone, Epstein-Barr virus activation, redox potential, cyclic voltammetry, anti-tumor promoting effect

ジャーナルフリー

2001 年 49 巻 9 号 p. 1214-1216

DOI https://doi.org/10.1248/cpb.49.1214

詳細

抄録

The redox potentials have been determined for nine azaanthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the azaanthraquinones on Epstein-Barr virus early antigen (EBV-EA) activation. It has further been shown that the correlation can be made better by introducing an electronic property, i.e., the atomic charge at O¹¹ as an additional parameter.

責任著者(Corresponding author)