Cycloartane Glycosides from the Rhizomes of Cimicifuga racemosa and Their Cytotoxic Activities

Kazuki Watanabe; Yoshihiro Mimaki; Hiroshi Sakagami; Yutaka Sashida

doi:10.1248/cpb.50.121

Notes

Cycloartane Glycosides from the Rhizomes of Cimicifuga racemosa and Their Cytotoxic Activities

Kazuki Watanabe, Yoshihiro Mimaki, Hiroshi Sakagami, Yutaka Sashida

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Keywords: Cimicifuga racemosa, Ranunculaceae, cycloartane glycoside, cytotoxic activity, HSC-2 cell

JOURNAL FREE ACCESS

2002 Volume 50 Issue 1 Pages 121-125

DOI https://doi.org/10.1248/cpb.50.121

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Abstract

Phytochemical analysis of the rhizomes of Cimicifuga racemosa (Ranunculaceae) resulted in the isolation of twelve cycloartane glycosides (1—12), including four new ones (4—6, 12). The structures of the new compounds were determined by spectroscopic analysis, including two-dimensional (2D) NMR data, and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against human oral squamous cell carcinoma (HSC-2) cells and normal human gingival fibroblasts (HGF).

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