Notes
A Concise Synthesis of Furostifoline by Tetrabutylammonium Fluoride-Promoted Indole Ring Formation
2002 年 50 巻 1 号 p. 143-145
詳細
2002 年 50 巻 1 号 p. 143-145
Furostifoline, a furo[3, 2-a]carbazole alkaloid, was synthesized in 10% overall yield in four steps from 2-acetyl-3-bromofuran. The key step of this synthesis was the 2-substituted indole formation with tetrabutylammonium fluoride (TBAF) from 2-(2-propenyl)-3-((2-ethoxycarbonylamino)phenylethynyl)furan, which was easily prepared from ethyl 2-ethynylphenylcarbamate with 3-bromo-2-(2-propenyl)furan by the Sonogashira reaction.
