Trypanocidal Terpenoids from Laurus nobilis L.

Nahoko Uchiyama; Keiji Matsunaga; Fumiyuki Kiuchi; Gisho Honda; Akiko Tsubouchi; Junko Nakajima-Shimada; Takashi Aoki

doi:10.1248/cpb.50.1514

Notes

Trypanocidal Terpenoids from Laurus nobilis L.

Nahoko Uchiyama, Keiji Matsunaga, Fumiyuki Kiuchi, Gisho Honda, Akiko Tsubouchi, Junko Nakajima-Shimada, Takashi Aoki

著者情報

キーワード: Laurus nobilis, Trypanosoma cruzi, p-menthane hydroperoxide, guaianolide, Lauraceae

ジャーナルフリー

2002 年 50 巻 11 号 p. 1514-1516

DOI https://doi.org/10.1248/cpb.50.1514

詳細

抄録

Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 μM, respectively.

責任著者(Corresponding author)

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