Novel and Efficient Synthesis of 4-Dimethylamino-2-glycosylaminoquinazolines by Cyclodesulfurization of Glycosyl Thioureas with Dimethylcyanamide

Yasuo Gama; Isao Shibuya; Masao Shimizu

doi:10.1248/cpb.50.1517

Notes

Novel and Efficient Synthesis of 4-Dimethylamino-2-glycosylaminoquinazolines by Cyclodesulfurization of Glycosyl Thioureas with Dimethylcyanamide

Yasuo Gama, Isao Shibuya, Masao Shimizu

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Keywords: quinazoline, glycosyl thiourea, dimethylcyanamide, silver triflate, cyclodesulfurization

JOURNAL FREE ACCESS

2002 Volume 50 Issue 11 Pages 1517-1519

DOI https://doi.org/10.1248/cpb.50.1517

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Abstract

4-Dimethylamino-2-glycosylaminoquinazoline derivatives were synthesized by cyclodesulfurization of N-aryl-N′-glycosyl thioureas with dimethylcyanamide in the presence of silver triflate in good yields.

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