Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Enzyme Inhibitory Constituents from Duranta repens
Itrat AnisSaeed AhmedAbdul MalikAmsha YasinM. Iqbal Choudary
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2002 Volume 50 Issue 4 Pages 515-518

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Abstract

Isoprenylated flavonoids 5,7-dihydroxy-3′-(2-hydroxy-3-methyl-3-butenyl)-3,6,4′-trimethoxyflavone (1), 3,7-dihydroxy-3′-(2-hydroxy-3-methyl-3-butenyl)-5,6,4′-trimethoxyflavone (2) and an isoprenylated acetophenone derivative (3) have been isolated from Duranta repens along with known compounds, 5-hydroxy-3,6,7,4′-tetramethoxyflavone (4), rosenonolactone (5), 6,7-dimethoxycoumarin (6), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (7) and 5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol (8), isolated for the first time from this species. Their structures and the relative configuration were determined by spectroscopic methods (1H- and 13C-NMR, IR, UV and MS) and two-dimensional (2D)-NMR experiments. The compounds 1—5 showed inhibitory activity against prolyl endopeptidase while 4 and 5 were also active against thrombin.

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© 2002 The Pharmaceutical Society of Japan
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