Synthesis and Fasciolicidal Activity of 5-Chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole

Alicia Hernández-Campos; Froylán Ibarra-Velarde; Yolanda Vera-Montenegro; Norma Rivera-Fernández; Rafael Castillo

doi:10.1248/cpb.50.649

Notes

Synthesis and Fasciolicidal Activity of 5-Chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole

Alicia Hernández-Campos, Froylán Ibarra-Velarde, Yolanda Vera-Montenegro, Norma Rivera-Fernández, Rafael Castillo

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Keywords: fasciolicidal activity, bioisostere, benzimidazole synthesis, Fasciola hepatica

JOURNAL FREE ACCESS

2002 Volume 50 Issue 5 Pages 649-652

DOI https://doi.org/10.1248/cpb.50.649

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Abstract

The synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole (6) is described. Compound 6 showed 100% activity in vitro at 146.70 and 29.34 μM concentrations. It also completely removed 3-d and 10-week-old Fasciola hepatica in sheep at a dose of 15 mg/kg.

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