Cytotoxic and Apoptosis-Inducing ent-Kaurane-Type Diterpenoids from the Japanese Liverwort Jungermannia truncata N<small>EES</small>

Fumihiro Nagashima; Masuo Kondoh; Toshinari Uematsu; Akiko Nishiyama; Sayaka Saito; Masao Sato; Yoshinori Asakawa

doi:10.1248/cpb.50.808

Regular Articles

Cytotoxic and Apoptosis-Inducing ent-Kaurane-Type Diterpenoids from the Japanese Liverwort Jungermannia truncata NEES

Fumihiro Nagashima, Masuo Kondoh, Toshinari Uematsu, Akiko Nishiyama, Sayaka Saito, Masao Sato, Yoshinori Asakawa

著者情報

キーワード: Jungermannia truncata, liverwort, gymnomitrane (=barbatane)-type, ent-kaurane-type, cytotoxic activity, apoptosis

ジャーナルフリー

2002 年 50 巻 6 号 p. 808-813

DOI https://doi.org/10.1248/cpb.50.808

詳細

抄録

Five new ent-kaurane-type diterpenoids and a new gymnomitrane (=barbatane)-type sesquiterpenoid have been isolated from the Japanese liverwort Jungermannia truncata NEES, together with twelve previously known ent-kaurane-type diterpenoids. The structures of the new compounds were elucidated by two-dimensional (2D) NMR experiments and chemical reaction. Some of the isolated compounds showed cytotoxicity against human leukemia cell lines and induced apoptosis.

責任著者(Corresponding author)

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